Cancer Biomarker Discovery

Cancer Biomarker Discovery

The MDRG is engaged in novel molecular target discovery research, in collaboration with clinical colleagues at GUH, to identify and evaluate novel small RNA biomarkers associated with cancer. The current research focus of the group includes the following collaborative cancer research programmes:   Investigation of specific miRNAs as diagnostic biomarkers of breast cancer in patients diagnosed with a variety of molecular sub‐types of breast cancer, in collaboration with Professor Michael Kerin, Professor of Surgery at NUIG and Consultant Surgeon at GUH. Candidate miRNA biomarkers identified are being incorporated into rapid near‐patient molecular tests for clinical evaluation, with the ultimate goal to develop reliable, accurate tests for use in breast cancer screening clinics.   The design, development and application of molecular assays for detection of specific genetic mutations associated with a range of haematological malignancies using in vitro amplification (PCR) and Next Generation Sequencing technologies. This research is being carried out in collaboration with clinical collaborators at GUH, with the objective of developing molecular tests for early and accurate diagnosis of genetic mutations associated with haematological malignancies, to ensure appropriate and effective clinical intervention, therapeutic monitoring and disease management.