Centre for Chromosome Biology (CCB)

About Us

The Centre for Chromosome Biology (CCB) at NUI Galway in Ireland hosts an interactive network of researchers investigating topics linked to the biology of genomes. We are interested in understanding the molecular mechanisms underlying chromosome replication, segregation, repair, evolution, chromatin regulation and transcription.

“These processes are fundamental to our growing understanding of genetics and epigenetics, and have important implications for cancer and disease”.

The Centre currently comprises 11 groups with over 90 researchers and support staff. We have a range of technologies available for studying chromosome biology at the molecular, cellular and organismal level.

Our Research Areas

Epigentics

Epigentics

Epigenetic regulation of gene expression and histone modifications in normal development and disease.

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Replication

Replication

Chromatin replication involves duplicating DNA while maintaining the epigenetic information. These processes are critical for genome stability and for preserving cell-type identity.

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Centrosomes

Centrosomes

Centrosome abnormalities and amplification are common characteristics of tumour cells. Aneuploidy and chromosomal instability are highly correlated with the appearance of multiple centrosomes.

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Nucleolus

Nucleolus

Our aims are to elucidate the chromosomal context of nucleolar organizer regions (NORs) and determine how their structure facilitates nucleolar formation.

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Trinucleotide Repeats

Trinucleotide Repeats

Mutagenesis is incredibly frequent at trinucleotide repeats in families with certain hereditary neurological diseases. These site-specific expansions, or gains of triplet repeats, occur in cells that appear otherwise normal.

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Nucleosomes

Nucleosomes

Chromatin is the substrate for most processes that occur in the eukaryotic cell nucleus due to its role as the universal genome packaging state. The nucleosome is the fundamental repeating subunit of chromatin so it is unsurprising that the histone proteins organising this structure are highly conserved.

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Centromeres

Centromeres

Mitosis and meiosis are fundamental cellular processes required for the correct transmission of genetic material during cell division cycles. Centromeres are key regions of eukaryotic chromosomes where the kinetochore assembles to ensure proper chromosome segregation during mitosis and meiosis.

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DNA Damage

DNA Damage

DNA damage response pathways in human mesenchymal stem cells and normal primary melanocytes. Mechanistic investigation of the cellular response to DNA damage-induced replication arrest.

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