Epigenetic regulation of gene expression and histone modifications in normal development and disease.

Chromatin replication involves duplicating DNA while maintaining the epigenetic information. These processes are critical for genome stability and for preserving cell-type identity.

Centrosome abnormalities and amplification are common characteristics of tumour cells. Aneuploidy and chromosomal instability are highly correlated with the appearance of multiple centrosomes.

Our aims are to elucidate the chromosomal context of nucleolar organizer regions (NORs) and determine how their structure facilitates nucleolar formation.

Mutagenesis is incredibly frequent at trinucleotide repeats in families with certain hereditary neurological diseases. These site-specific expansions, or gains of triplet repeats, occur in cells that appear otherwise normal.

Chromatin is the substrate for most processes that occur in the eukaryotic cell nucleus due to its role as the universal genome packaging state. The nucleosome is the fundamental repeating subunit of chromatin so it is unsurprising that the histone proteins organising this structure are highly conserved.

Mitosis and meiosis are fundamental cellular processes required for the correct transmission of genetic material during cell division cycles. Centromeres are key regions of eukaryotic chromosomes where the kinetochore assembles to ensure proper chromosome segregation during mitosis and meiosis.

DNA damage response pathways in human mesenchymal stem cells and normal primary melanocytes. Mechanistic investigation of the cellular response to DNA damage-induced replication arrest.