• Development of novel rapid glycoanalytical tools 
• Role of glycans in host-microbe interactions in the gut
• Cell surface glycans and lectins in the intervertebral disc 
• Exposure studies of metallic nanoparticles on marine organisms
• Glycobioinformatics 

S. Cunningham, J. Q. Gerlach, M. Kane and L. Joshi. Analyst, 2010, Epub ahead of print DOI: 10.1039/c0an00276c.

Nandakumar V, La Belle JT, Reed J, Shah M, Cochran C, Joshi L, and Alford TL. 2008. A Methodology for Rapid Detection of Salmonella typhimurium using label free Electrochemical Impedance Spectroscopy. Biosensors and Bioelectronics. In Press.

Kilcoyne M, Shah M, Gerlach JQ, Bhavanandan VP, Nagaraj VJ, Smith AD, Fujiyama K, Sommer U, Costello CE, Joshi L. Mucin-type O-glycosylation and O-GlcNAc modification on rice alcohol soluble proteins. Journal of Plant Physiology. In Press. Link

Foley KJ, Forzani ES, Joshi L and Tao NJ. 2008. Detection of lectin-glycan interaction using high resolution-surface plasmon resonance. Analyst. 133(6):744-6. Link

Svarovsky, SA and Joshi L. 2008. Biocombinatorial Selection of Carbohydrate Binding Agents of Therapeutic Significance, Current Drug Discovery Technologies. 2008, 5(1), 20-28. Link

Quinn DJ, Cunningham S, Walker B, Scott CJ Activity-based selection of a proteolytic species using ribosome display. Biochem Biophys Res Commun. 2008 May 23;370(1):77-81. Epub 2008 Mar 14

Shaw, I, O'Reilly, A, Charleton, M, Kane, M. (2008) Development of a high-affinity anti-domoic acid sheep scFv and its use in detection of the toxin in shellfish. Analytical Chemistry. 80, 3205-3212. Link

Wilson JW, Ott CM, Honer Zu Bentrup K, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Fernandez D, Richter E, Shah M, Kilcoyne M, Joshi L, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, Goulart C, Rupert M, Stodieck L, Stafford P, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Allen P, Baker-Coleman C, Hammond T, Vogel J, Nelson R, Pierson DL, Stefanyshyn-Piper HM, Nickerson CA. 2007. Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. Proc Natl Acad Sci U S A. 104(41):16299-304. Link

La Belle JT, Bhavsar K, Fairchild A, Das A, Sweeney J, Alford TL, Wang J, Bhavanandan VP, Joshi L. 2007. A Cytokine Biosensor for Multiple Sclerosis Detection Based Upon Label-Free Electrochemical Impedance Spectroscopy. Biosensor and Bioelectronics. 23(3):428-31. Link

La Belle JT, Gerlach JQ, Svarovsky S, Joshi L. 2007. Label-Free Real-Time Impedimetric Detection of Carbohydrate-Lectin Interactions. Analytical Chemistry. 15;79(18):6959-64. Link

Kilcoyne M and Joshi L. 2007. Carbohydrates in therapeutics. Cardiovasc Hematol Agents Med Chem. 5(3):186-97. Link

Anissa N. Elayadi, Kausar N. Samli, Ludmila Prudkin, Ying-Horng Liu, Aihua Bian, Xian-Jin Xie, Ignacio I. Wistuba, Jack A. Roth, Michael J. McGuire, and Kathlynn C. Brown (2007) ?A peptide selected by biopanning identifies the integrin {alpha}v{beta}6 as a prognostic biomarker for non-small cell lung cancer? Cancer Research, 67(12): 5889-5895. Link

Koch, M., Camp, S., Collen, T., Avila, D., Salomonsen, J., Wallny, H-J., van Hateren, A., Hunt, L, Jacob, J.P., Johnston, F., Marston, D.A., Shaw, I., Dunbar., P.R., Cerundolo, V., Jones, E.V., Kaufman, J. (2007) Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding Immunity, 27(6) 885 - 899. Link

Shaw, I, Powell, T.J., Marston, D.A., Baker, K., van Hateren, A., Riegert, P., Wiles, M.V., Milne, S., Beck, S., Kaufman, J. (2007) Different evolutionary histories of the two classical class I genes BF1 and BF2 illustrate drift and selection within the stable MHC haplotypes of chickens. Journal of Immunology 178(9) 5744-5752. Link

Hu X, O'Hara L, White S, Magner E, Kane M, Wall JG. Optimisation of production of a domoic acid-binding scFv antibody fragment in Escherichia coli using molecular chaperones and functional immobilisation on a mesoporous silicate support. Protein Expr Purif. 2007 Mar;52(1):194-201. Epub 2006 Aug 24

Z. Dai, A.-N. Kawde, Y. Xiang, J.T. La Belle, J.Q. Gerlach, V.P. Bhavanandan, L. Joshi*, J. Wang*. 2006. Nanoparticle-Based Bioelectronic Sensing of Glycan-Lectin Interactions. J Am Chem Soc. 128: 10018-10019. * Corresponding authors. Link

Tangkuaram, T., J.Q. Gerlach, Y. Xiang, A.-N. Kawde, Z. Dai, V.P. Bhavanandan, J.T. La Belle, W. Veerasai, L. Joshi*, J. Wang*. 2006. Sensitive and Rapid Electrochemical Bioassay of Glycosidase Activity. The Analyst. 131: 889-891. * Corresponding authors. Link

Kilcoyne M, Moran AP, Shashkov AS, Senchenkova SN, Ferris JA, Corcoran AT, Savage AV Molecular origin of two polysaccharides of Campylobacter jejuni 81116. FEMS Microbiol Lett. 2006 Oct;263(2):214-22

O'Dowd C, Mothersill CE, Cairns MT, Austin B, McClean B, Lyng FM, Murphy JE. The release of bystander factor(s) from tissue explant cultures of rainbow trout (Onchorhynchus mykiss) after exposure to gamma radiation. Radiat Res. 2006 Oct;166(4):611-7

Gillis EH, Traynor I, Gosling JP, Kane M. Improvements to a surface plasmon resonance-based immunoassay for the steroid hormone progesterone. J AOAC Int. 2006 May-Jun;89(3):838-42

Keating AF, Smith TJ, Ross RP, Cairns MT. A single nucleotide polymorphism in the bovine beta-casein promoter region across different bovine breeds. J Dairy Res. 2006 May;73(2):193-6. Epub 2006 Feb 14

Johnson MC, Sangrador-Vegas A, Smith TJ, Cairns MT. Cloning and characterization of two genes encoding rainbow trout homologues of the IFITM protein family. Vet Immunol Immunopathol. 2006 Apr 15;110(3-4):357-62.

McGuire, Michael J., Samli, Kausar N., Chang, Ya-Ching, Brown, Kathlynn C. (2006) ?Novel Ligands for Cancer Diagnosis: Selection of Peptide Ligands for Identification and Isolation of B Cell Lymphomas? Experimental Hematology, 34: 443-454. Link

Oyama, Tsukasa, Rombel, Irene T., Samli, Kausar N., Zhou, Xin, and Brown, Kathlynn C ?Isolation of multiple cell-binding ligands from different phage displayed-peptide libraries? (2006) Biosensors & Bioelectronics, 21: 1867-1875. Link

Kilcoyne M, Shashkov AS, Perepelov AV, Nazarenko EL, Gorshkova RP, Ivanova EP, Widmalm G, Savage AV Structure of the O-specific polysaccharide from Shewanella japonica type strain KMM 3299T containing the rare amino sugar Fuc4NAc. Carbohydr Res. 2005 Jun 13;340(8):1557-61

James JE, Gregg ME, Kane M, Harte F. Dietary caffeine, performance and mood: enhancing and restorative effects after controlling for withdrawal reversal. Neuropsychobiology. 2005;52(1):1-10. Epub 2005 Jun 3

Flynn CR, Brophy CM, Furnish EJ, Komalavilas P, Tessier D, Thresher J, Joshi L. 2005. Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical artery smooth muscle. J Appl Physiol. 98(5):1836-45. Link

Lopes LB, Brophy CM, Furnish E, Flynn CR, Sparks O, Komalavilas P, Joshi L, Panitch A, Bentley MV. 2005. Comparative study of the skin penetration of protein transduction domains and a conjugated peptide. Pharm Res. 22(5):750-7. Link

Joshi L, Lopez LC. Bioprospecting in plants for engineered proteins. Curr Opin Plant Biol. 2005 Apr;8(2):223-6. Review

Samli, Kausar N., McGuire, Michael J., Newgard, Christopher B., Johnston, Stephen Albert, Brown, Kathlynn C. (2005) ?Peptide mediated targeting to the Islets of Langerhans? Diabetes, 54: 2103-2108. Link

De, Jitakshi, Chang, Ya-Ching, Samli, Kausar N., Schisler, Jonathan, Newgard, Christopher B., Johnston, Stephen Albert, Brown, Kathlynn C., (2005) "Isolation of a Mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library\" Molecular Biosystems, 1: 149-157. Link

Rogers PJ, Heatherley SV, Hayward RC, Seers HE, Hill J, Kane M. Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology (Berl). 2005 Jun;179(4):742-52.

Keating AF, Stanton C, Murphy JJ, Smith TJ, Ross RP, Cairns MT. Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows. Mamm Genome. 2005 Mar;16(3):184-93

Dreiza CM, Brophy CM, Komalavilas P, Furnish EJ, Joshi L, Pallero MA, Murphy-Ullrich JE, von Rechenberg M, Ho YS, Richardson B, Xu N, Zhen Y, Peltier JM, Panitch A. Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics. FASEB J. 2005 Feb;19(2):261-3.

Johnson MC, Sangrador-Vegas A, Smith TJ, Cairns MT. Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) matrix metalloproteinase-9. Fish Shellfish Immunol. 2004 Nov;17(5):499-503

Fletcher SP, Geyer BC, Smith A, Evron T, Joshi L, Soreq H, Mor TS. 2004. Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants. Plant Mol Biol.; 55(1):33-43. Link

McLemore EC, Tessier DJ, Flynn CR, Furnish EJ, Komalavilas P, Thresher JS, Joshi L, Stone WM, Fowl RJ, Brophy CM. Transducible recombinant small heat shock-related protein, HSP20, inhibits vasospasm and platelet aggregation. Surgery. 2004 Sep;136(3):573-8

Tessier DJ, Komalavilas P, Liu B, Kent CK, Thresher JS, Dreiza CM, Panitch A, Joshi L, Furnish E, Stone W, Fowl R, Brophy CM. 2004.Transduction of peptide analogs of the small heat shock-related protein HSP20 inhibits intimal hyperplasia. J Vasc Surg. 40(1):106-14. Link

McGuire, Michael J., Sykes, Kathryn F., Samli, Kausar N., Timares, Laura, Barry, Michael A., Stemke-Hale, Katherine, Tagliaferri, Frank, Logan, Mark, Jansa, Kimberly, Takashima, Akira, Brown, Kathlynn C., Johnston, Stephen Albert (2004) ?A Library-Selected, Langerhans Dendretic Cell-Targeting Peptide Enhances an Immune Response? DNA and Cell Biology, 23: 742-752. Link

McGuire, Michael J., Samli, Kausar N., Johnston, Stephen Albert, Brown, Kathlynn C. (2004) ?In Vitro Selection of a Peptide with High Selectivity for Cardiomyocytes In Vivo? J. Mol. Biol. 342: 171-182. Link

Kilcoyne M, Perepelov A, Shashkov AS, Nazarenko EL, Ivanova EP, Gorshkova NM, Gorshkova RP, Savage AV. Structure of an acidic O-specific polysaccharide from marine bacterium Shewanella fidelis KMM 3582T containing Nepsilon-[(S)-1-carboxyethyl]-Nalpha-(D-galacturonoyl)-L-lysine. Carbohydr Res. 2004 Jun 22;339(9):1655-61

Xu X, Ruan D, Jin Y, Shashkov AS, Senchenkova SN, Kilcoyne M, Savage AV, Zhang L. Chemical structure of aeromonas gum--extracellular polysaccharide from Aeromonas nichidenii 5797. Carbohydr Res. 2004 Jun 22;339(9):1631-6

Kilcoyne M, Perepelov AV, Tomshich SV, Komandrova NA, Shashkov AS, Romanenko LA, Knirel YA, Savage AV. Structure of the O-polysaccharide of Idiomarina zobellii KMM 231T containing two unusual amino sugars with the free amino group, 4-amino-4,6-dideoxy-D-glucose and 2-amino-2-deoxy-L-guluronic acid. Carbohydr Res. 2004 Feb 25;339(3):477-82

McConnell EJ, McLemore EC, Talac R, Joshi L, Nelson H. 2004. Depletion of activated Vbeta8+ T cells disrupts bispecific antibody directed antitumor immunity. J Surg Res.;122(1):103-12. Link

Wang Y, Zhang M, Ruan D, Shashkov AS, Kilcoyne M, Savage AV, Zhang L. Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of Poria cocos. Carbohydr Res. 2004 Jan 22;339(2):327-34

Shah MM, Fujiyama K, Flynn CR, Joshi L. Sialylated endogenous glycoconjugates in plant cells. Nat Biotechnol. 2003 Dec;21(12):1470-1.

Nazarenko EL, Komandrova NA, Gorshkova RP, Tomshich SV, Zubkov VA, Kilcoyne M, Savage AV. Structures of polysaccharides and oligosaccharides of some Gram-negative marine Proteobacteria. Carbohydr Res. 2003 Nov 14;338(23):2449-57. Review

Flynn CR, Komalavilas P, Tessier D, Thresher J, Niederkofler EE, Dreiza CM, Nelson RW, Panitch A, Joshi L, Brophy CM. Transduction of biologically active motifs of the small heat shock-related protein HSP20 leads to relaxation of vascular smooth muscle. FASEB J. 2003 Jul;17(10):1358-60. Epub 2003 May 8

Tessier DJ, Komalavilas P, Panitch A, Joshi L, Brophy CM. The small heat shock protein (HSP) 20 is dynamically associated with the actin cross-linking protein actinin. J Surg Res. 2003 May 1;111(1):152-7

Kilcoyne M, Shashkov AS, Senchenkova SA, Knirel YA, Vinogradov EV, Radziejewska-Lebrecht J, Galimska-Stypa R, Savage AV. Structural investigation of the O-specific polysaccharides of Morganella morganii consisting of two higher sugars. Carbohydr Res. 2002 Oct 8;337(18):1697-702

Joshi L, Van Eck JM, Mayo K, Di Silvestro R, Blake Nieto ME, Ganapathi T, Haridas V, Gutterman JU, Arntzen CJ. Metabolomics of plant saponins: bioprospecting triterpene glycoside diversity with respect to mammalian cell targets. OMICS. 2002;6(3):235-46

Ishikawa M, Sengoku K, Tamate K, Takaoka Y, Kane M, Fottrell PF. The clinical usefulness of salivary progesterone measurement for the evaluation of the corpus luteum function. Gynecol Obstet Invest. 2002;53(1):32-7

Martin SA, Caplice NC, Davey GC, Powell R. EST-based identification of genes expressed in the liver of adult Atlantic salmon (Salmo salar). Biochem Biophys Res Commun. 2002 Apr 26;293(1):578-85

Flanagan AF, Callanan KR, Donlon J, Palmer R, Forde T, Kane M. (2001) A cytotoxicity assay for the detection and differentiation of two families of shellfish toxins. Toxicon 39/7, 1021-1027.

Shaw, I and Davison, T.F. (2000) Protection from IBDV-induced bursal damage by a recombinant fowlpox vaccine, fpIBD1, is dependent on the titre of challenge virus and chicken genotype. Vaccine 18(28):3230-3241. Link

Tamate, K., Charleton, M., Gosling, J.P., Egan, D., Ishikawa, M., Fottrell, P.F., Kane, M.M. (1997) Direct colorimetric monoclonal antibody enzyme immunoassay for estradiol-17b in saliva. Clin Chem 43:7,1159-1164. Link

Lenihan Launches Science Foundation Ireland-funded Alimentary Glycoscience Research Cluster at NUI Galway - October 2009

Tánaiste announces establishment of 5 New Science Foundation Ireland ?Strategic Research Clusters' - February 2009
Tánaiste and Minister for Enterprise, Trade and Employment, Mary Coughlan T.D., announced the establishment of 5 new Science Foundation Ireland (SFI) Strategic Research Clusters (SRCs), representing a €23.9million investment in ground-breaking, collaborative research activities involving seven academic institutions and 22 companies.
Full Press Release

 
Tánaiste, Mary Coughlan T.D., Director General, SFI, Frank Gannon and the AGRC Team.

Irish Organisations & Institutions